Cornelia de Moor is an RNA biologist with a long term interest in the untranslated regions (UTRs) and poly(A) tails of mRNAs and their effects on protein synthesis and mRNA degradation.
As a postgraduate student she studied the translational control of insulin like growth factor by its alternative 5′ UTRs in human tissues. During my postdoctoral research, she investigated the role of translational control in Xenopus oocyte maturation and made significant contributions to the elucidation the translational repression of cyclin B1 and its activation by cytoplasmic polyadenylation. Her work was instrumental in formulating the first molecular model for translational control by a 3′ untranslated region, the maskin model.
In 2000, she started her own laboratory as a lecturer in the School of Biomedical Sciences at the University of Nottingham, transferring to the School of Pharmacy in 2005. In 2013, she was promoted to associate professor. Most of her current work is on the role of mRNA polyadenylation in gene expression and the therapeutic potential of the polyadenylation inhibitor cordycepin, which is isolated from the caterpillar fungus Cordyceps militaris.
Her laboratory uses mathematical modelling, standard molecular biology techniques, as well as a number of novel techniques developed in our laboratory, such as methods for measuring poly(A) tail size, mathematical modeling of mRNA decay and thiouridine labelling. In collaboration with others, she is studying the role of mRNA polyadenylation and the effect of cordycepin on the growth of breast cancer cells and on osteoarthritis pain. Her research is funded by grants from the BBSRC and Arthritis Research UK, as well as a donation from Geo-rope.
For further details: Cornelia De Moor