Dr Karen Robinson’s research group is mostly focused on the human bacterial pathogen Helicobacter pylori, which is the main cause of stomach ulcers and gastric cancer. Members of the group are working on a range of projects including antimicrobials and antimicrobial resistance, the microbiota of the GI tract, mucosal immunity and inflammation (with a particular interest in regulatory T and B cell responses), iron deficiency anaemia, development of novel diagnostics, H. pylori genomics, as well as mechanisms of disease pathogenesis and gastric carcinogenesis.
The group is interested in the mechanisms by which H. pylori virulence factors (such as the cag pathogenicity island and duodenal ulcer promoting gene A) interact with cells of the host to provoke a more severe inflammatory response, and the molecules which induce immunosuppressive immune responses. They are also exploring the links between infections (including H. pylori) and a reduced risk of allergy and autoimmune diseases. They have a particular interest in how H. pylori mediates protection against multiple sclerosis.
The group collaborates with a diverse team of scientists and clinicians from within Nottingham, the UK and world-wide, including gastroenterologists, microbiologists, immunologists, epidemiologists, histopathologists, mathematicians, neurologists, cancer biologists, bioinformaticians and experts in drug delivery.
For further details: Dr Karen Robinson