Gastrointestinal & Liver

Cutting-edge science translated into innovative treatments, tests and clinical management

We work with a number of national and international research groups which all help to inform and accelerate our research in Nottingham.

  • Hepatitis C Virus (HCV) Group co-ordinates the world’s largest HCV cohort (n=11,000), has £8.5M in active grants and leads the discovery of potent, broadly neutralising human monoclonal antibodies, now patented and in trial.
  • Clostridia Research Group, underpinned by our £14.3M BBSRC/EPSRC Centre, is a world-class discovery unit in clostridial genetics, pathogenesis and synthetic biology with four recent filed patents.
  • Helicobacter Group is an international leader in Hp genetics, virulence, immunity and treatment targets whose work underpins modern Hp virulence testing.
  • UK-leading GI Epidemiology Group provides expert methodological support, and the Nottingham Clinical Trials Unit provides support for early patient-based translational study.
  • Stem Cell Biology Group, with its specific stem cell based disease models; FRAME Alternatives Laboratory with its state-of-the-art cell biology facility (£1M) with expertise in culturing primary human cells; and the UK top-ranked School of Pharmacy, will translate GI and liver drug discovery/formulation programmes.
  • We have strong links with the MRC/ARUK Centre (£2M) for Musculoskeletal Ageing Research resulting in internationally leading in in-vivo human, whole body physiological investigations within School of Nutritional Sciences, which underpin the development of new treatments for disorders of gastrointestinal and liver physiology and metabolism.

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