Delegates at the NIHR Nottingham Biomedical Research Centre (BRC) Symposium heard how MRI metrics can be considered as a basis for ‘evidence’ presented by clinical trials.
This workshop, entitled MRI in Clinical Trials, was hosted by Dr Rob Dineen, Associate Professor of Neuroimaging and Consultant Neuroradiologist, Dr Chris Tench, Research Fellow and Professor Paul Morgan, Honorary Chair, all of whom are based at the University of Nottingham.
MRI is widely used to provide outcome measures for clinical trials, and features in many studies within the NIHR Nottingham BRC portfolio.
To begin the workshop – one of several which were held on 19 June at the University of Nottingham’s Jubilee Conference Centre at Jubilee Campus, which spanned various BRC research themes – Dr Tench reviewed the core principles for evaluating evidence in clinical trials using MRI data.
Dr Dineen later considered approaches to establishing the reliability of different MRI metrics for multi-centre clinical trials, considering the published local and external examples.
Finally, Prof. Paul Morgan reviewed a practical example of an international multi-centre clinical trial which highlighted challenges and solutions for the standardisation of MRI protocols, data collation and analysis.
The workshop concluded with an interactive panel discussion with the audience, addressing the topics covered in the session.